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InChiKey: TYCGNZLSLVRAAR-MCDZGGTQSA-N
Driven by its fluoropropyl pyrrolidinyl side chain
as well as the phosphorylation of RNA polymerase II on the CTD repeats at Ser2 Ser5
InChi: InChI=1S/C20H17FN2O4S/c1-13-10-15(14-6-3-2-4-7-14)11-18(19(13)21)20(25)22-23-28(26
SN-38 Size:Solid 2 mg vegetablesSN 38 is the active metabolite of irinotecan (an analog of camptothecin a topoisomerase I inhibitor); it is 1000 times more active than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN 38 relative to irinotecan varies from 2 to 2000 fold. SN38 is metabolized via glucoronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolization of irinotecan predicts irinotecan toxicity, as it cannot be
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