EGFR mutant-IN-1 Catalog No.:M17489-C After oral dosing

After oral dosing

twice daily) causes an inhibition of tumor growth in NCr athymic mice bearing established SW620 human colorectal cancer xenografts

Chemical Name: 2-{[(1R)-1-[7-methyl-2-(morpholin-4-yl)-4-oxo-4H-pyrido[1

Saccharopine

Formula: C19H15Cl2NO4S

EGFR mutant-IN-1 Catalog No.:M17489-C After oral dosingEGFR mutant IN 1, a 5 methylpyrimidopyridone derivative, is a potent and selective EGFRL858R T790M C797S mutant inhibitor with an IC50 of 27. 5 nM, while being a significantly less potent for EGFRWT (IC50 >1. 0 M). Product information Molecular Weight: 632. 17 Formula: C34H39ClFN7O2 Chemical Name: (R) 6 (2 chloro 3 fluorophenyl) 5 methyl 2 ((3 methyl 4 (4 methylpiperazin 1 yl)phenyl)amino) 8 (1 propionylpiperidin 3 yl)pyrido[2, 3 d]pyrimidin 7(8H) one