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is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM)
In R132H-IDH1 glioma xenografts (TS603)
often upregulated or mutated in a variety of cancer cells
(2014) Leukemia
apoptosis through the mitochondrial pathway
OG-L002 - LSD1 Inhibitor. CAS# 1357302-64-7 60281 is a highly specific inhibitorOG L002, CAS No. 1357302 64 7, is a highly potent and specific inhibitor of Lysine Specific Demethylase 1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~20 nM, and has moderate inhibitory activity against monoamine oxidases MAO A and MAO B with IC50 ~1. 38 M and 0. 72M respectively. It potently repressed herpes simplex virus (HSV) IE gene expression, genome replication, and reactivation from latency. OG L002 suppressed primary lytic
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